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KMID : 1137820140350030068
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의공학회지
2014 Volume.35 No. 3 p.68 ~ p.74
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Brain Connectivity Analysis using 18F-FDG-PET and 11C-PIB-PET Images of Normal Aging and Mild Cognitive Impairment Participants
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Son S.-J.
Park H.
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Abstract
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Recent research on mild cognitive impairment (MCI) has shown that cognitive and memory decline in this disease is accompanied by disruptive changes in the brain functional network. However, there have been no graph-theoretical studies using 11C-PIB PET data of the Alzheimer’s Disease or mild cognitive impairment. In this study, we acquired 18F-FDG PET and 11C-PIB PET images of twenty-four normal aging control participants and thirty individuals with MCI from ADNI (Alzheimer’s Disease Neuroimaging Initiative) database. Brain networks were constructed by thresholding binary correlation matrices using graph theoretical approaches. Both normal control and MCI group showed small-world property in 11C-PIB PET images as well as 18F-FDG PET images. 11C-PIB PET images showed significant difference between NC (normal control) and MCI over large range of sparsity values. This result will enable us to further analyze the brain using established graph-theoretical approaches for 11C-PIB PET images.
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KEYWORD
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Brain network analysis, Brain connectivity, PET, FDG, PIB, Mild cognitive impairment
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